Dorsal anterior cingulate cortex shows fMRI response to internal and external error signals

Nat Neurosci. 2004 May;7(5):497-8. doi: 10.1038/nn1238. Epub 2004 Apr 18.


In our event-related functional magnetic resonance imaging (fMRI) experiment, participants learned to select between two response options by trial-and-error, using feedback stimuli that indicated monetary gains and losses. The results of the experiment indicate that error responses and error feedback activate the same region of dorsal anterior cingulate cortex, suggesting that this region is sensitive to both internal and external sources of error information.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Analysis of Variance
  • Brain Mapping
  • Decision Making / physiology
  • Evoked Potentials / physiology*
  • Feedback / physiology
  • Female
  • Gyrus Cinguli / blood supply
  • Gyrus Cinguli / physiology*
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / methods*
  • Male
  • Mental Processes / physiology*
  • Photic Stimulation
  • Psychomotor Performance / physiology*