The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

Nat Med. 2004 May;10(5):484-6. doi: 10.1038/nm1042. Epub 2004 Apr 18.

Abstract

The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Apoptosis
  • Cocarcinogenesis
  • Eukaryotic Initiation Factor-4E / genetics
  • Eukaryotic Initiation Factor-4E / physiology*
  • Gene Expression
  • Genes, myc*
  • Lymphoma, B-Cell / etiology*
  • Lymphoma, B-Cell / genetics
  • Lymphoma, B-Cell / pathology
  • Mice
  • Mice, Transgenic
  • Protein Kinases / physiology
  • TOR Serine-Threonine Kinases

Substances

  • Eukaryotic Initiation Factor-4E
  • Protein Kinases
  • TOR Serine-Threonine Kinases
  • mTOR protein, mouse