Measurement of density and chemical concentration using a microfluidic chip

Lab Chip. 2003 Feb;3(1):19-21. doi: 10.1039/b211429a. Epub 2003 Feb 3.


A new microfluidic product for measuring fluid density, specific gravity and chemical concentration has been developed. At the core of this lab-on-a-chip sensor is a vacuum-sealed resonating silicon microtube. Measurements can be made with under a microliter of sample fluid, which is over 1000x less than is conventionally required. Since the product is MEMS-based the overall system size is a fraction of conventional density meters and it weighs much less than the traditional desk-top, temperature controlled, density meters. The syringe or pipette loaded system includes a dynamic temperature control system that operates between 0 degree C and 90 degree C with an accuracy of less than 0.01 degree C. Density measurement accuracies of 4 to 5 digits have been observed with aqueous solutions. Measurement examples and applications will be discussed.

MeSH terms

  • Equipment Design
  • Methanol / chemistry
  • Microchemistry* / instrumentation
  • Microchemistry* / methods
  • Microfluidics* / instrumentation
  • Microfluidics* / methods
  • Silicon Dioxide
  • Solutions / chemistry*
  • Surface Properties


  • Solutions
  • Silicon Dioxide
  • Methanol