Pharmacologic agents in stroke prevention, acute stroke therapy, and interventional procedures

J Vasc Interv Radiol. 2004 Jan;15(1 Pt 2):S87-101. doi: 10.1097/01.rvi.0000112975.88422.5d.


Pharmaceutical agents have moved far beyond just the aspirin and heparin that were the mainstays of stroke and interventional therapy as recently as 10 to 15 years ago. Our understanding of the mechanisms of thrombus formation and vascular response to damage as well as our armamentarium has tremendously improved in the past decade. Direct thrombin inhibitors, powerful antiplatelet agents, new fibrinolytic agents, and statins now allow far greater manipulation of the intraprocedural and postprocedural clot cascade and atherogenesis. It is mandatory that current-day interventionists understand the correct and appropriate use of these agents to achieve the desired outcomes of therapy.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Antithrombins / therapeutic use
  • Drug Therapy, Combination
  • Fibrinolytic Agents / therapeutic use
  • Heparin / therapeutic use
  • Humans
  • Intracranial Thrombosis / drug therapy
  • Platelet Aggregation Inhibitors / therapeutic use
  • Platelet Glycoprotein GPIIb-IIIa Complex / therapeutic use
  • Stroke / prevention & control*


  • Angiotensin-Converting Enzyme Inhibitors
  • Antithrombins
  • Fibrinolytic Agents
  • Platelet Aggregation Inhibitors
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Heparin