First diamino Daphniphyllum alkaloid, daphnipaxinin, with an unprecedented heterohexacyclic skeleton from Daphniphyllum paxianum

Org Lett. 2004 Apr 29;6(9):1401-4. doi: 10.1021/ol049756j.

Abstract

[structure: see text] The first diamino Daphniphyllum alkaloid, daphnipaxinin (1), with an unprecedented hexacyclic fused skeleton, along with a known alkaloid, daphnicyclidin A (2), was isolated from the stem of Daphniphyllum paxianum Rosenth. The structure and absolute stereochemistry of 1 were established by spectral methods, especially two-dimensional NMR techniques and CD analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / isolation & purification
  • Carbohydrate Conformation
  • Circular Dichroism
  • Heterocyclic Compounds, 4 or More Rings / chemistry*
  • Heterocyclic Compounds, 4 or More Rings / isolation & purification
  • Magnetic Resonance Spectroscopy
  • Plant Stems / chemistry
  • Plants, Medicinal / chemistry*
  • Stereoisomerism

Substances

  • Alkaloids
  • Heterocyclic Compounds, 4 or More Rings
  • daphnipaxinin