In vitro activity of terbinafine against medically important non-dermatophyte species of filamentous fungi

J Antimicrob Chemother. 2004 Jun;53(6):1086-9. doi: 10.1093/jac/dkh228. Epub 2004 Apr 21.


Objectives: The activity in vitro of terbinafine against 442 clinical isolates of several species of filamentous fungi was analysed.

Methods: A broth microdilution test was carried out following the National Committee for Clinical Laboratory Standards reference method, with modifications described previously.

Results: The geometric mean (GM) of MICs of terbinafine for non-Aspergillus fumigatus species was 0.24 mg/L whereas the GM for A. fumigatus rose as far as 2.92 mg/L. Terbinafine showed a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. However, some species such as Scedosporium spp., Fusarium spp., Scopulariopsis brevicaulis, and most of Mucorales exhibited high MICs of the allylamine with GMs >/= 4 mg/L.

Conclusions: Overall, the GM of MICs of terbinafine was 1.57 mg/L, but significant differences in susceptibilities were seen between genera and species.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / pharmacology
  • Antifungal Agents / pharmacology*
  • Fungi / drug effects*
  • Itraconazole / pharmacology
  • Microbial Sensitivity Tests
  • Naphthalenes / pharmacology*
  • Pyrimidines / pharmacology
  • Spain
  • Terbinafine
  • Triazoles / pharmacology
  • Voriconazole


  • Antifungal Agents
  • Naphthalenes
  • Pyrimidines
  • Triazoles
  • Itraconazole
  • Amphotericin B
  • Terbinafine
  • Voriconazole