Cerebral edema and cerebral hemorrhages in interleukin-10-deficient mice infected with Plasmodium chabaudi

Infect Immun. 2004 May;72(5):3054-8. doi: 10.1128/IAI.72.5.3054-3058.2004.

Abstract

During a Plasmodium chabaudi infection in interleukin-10 (IL-10) knockout mice, there is greater parasite sequestration, more severe cerebral edema, and a high frequency of cerebral hemorrhage compared with infection of C57BL/6 mice. Anti-tumor necrosis factor alpha treatment ameliorated both cerebral edema and hemorrhages, suggesting that proinflammatory responses contributed to cerebral complications in infected IL-10(-/-) mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Edema / etiology*
  • Brain Edema / immunology
  • Brain Edema / pathology
  • Cerebral Hemorrhage / etiology*
  • Cerebral Hemorrhage / immunology
  • Cerebral Hemorrhage / pathology
  • Female
  • Interleukin-10 / deficiency*
  • Interleukin-10 / genetics
  • Malaria, Cerebral / complications
  • Malaria, Cerebral / etiology*
  • Malaria, Cerebral / immunology*
  • Malaria, Cerebral / pathology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Plasmodium chabaudi* / pathogenicity
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors

Substances

  • Tumor Necrosis Factor-alpha
  • Interleukin-10