Abstract
During a Plasmodium chabaudi infection in interleukin-10 (IL-10) knockout mice, there is greater parasite sequestration, more severe cerebral edema, and a high frequency of cerebral hemorrhage compared with infection of C57BL/6 mice. Anti-tumor necrosis factor alpha treatment ameliorated both cerebral edema and hemorrhages, suggesting that proinflammatory responses contributed to cerebral complications in infected IL-10(-/-) mice.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Brain Edema / etiology*
-
Brain Edema / immunology
-
Brain Edema / pathology
-
Cerebral Hemorrhage / etiology*
-
Cerebral Hemorrhage / immunology
-
Cerebral Hemorrhage / pathology
-
Female
-
Interleukin-10 / deficiency*
-
Interleukin-10 / genetics
-
Malaria, Cerebral / complications
-
Malaria, Cerebral / etiology*
-
Malaria, Cerebral / immunology*
-
Malaria, Cerebral / pathology
-
Mice
-
Mice, Inbred C57BL
-
Mice, Knockout
-
Plasmodium chabaudi* / pathogenicity
-
Tumor Necrosis Factor-alpha / antagonists & inhibitors
Substances
-
Tumor Necrosis Factor-alpha
-
Interleukin-10