Oxygen radicals as key mediators in neurological disease: fact or fiction?

Ann Neurol. 1992;32 Suppl:S10-5. doi: 10.1002/ana.410320704.


A free radical is any species capable of independent existence that contains one or more unpaired electrons. Free radicals and other reactive oxygen species are frequently proposed to be involved in the pathology of several neurological disorders. Criteria for establishing such involvement are presented. Development of new methods for measuring oxidative damage should enable elucidation of the precise role of reactive oxygen species in neurological disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Free Radicals / metabolism*
  • Humans
  • Nervous System Diseases / metabolism*
  • Oxidation-Reduction
  • Oxygen / metabolism*


  • Free Radicals
  • Oxygen