Labdane diterpenes of Leonurus sibiricus

J Nat Prod. 2004 Apr;67(4):714-7. doi: 10.1021/np030480i.

Abstract

Seven new labdane diterpenes, sibiricinones A-E (1-4, 6) and 15-epi-sibiricinones D and E (5 and 7), and the flavone genkwanin were isolated from the aerial parts of Leonurus sibiricus. Sibiricinone D (4) and 15-epi-sibiricinone D (5), and sibiricinone E (6) and 15-epi-sibiricinone E (7), respectively, were isolated as C-15 epimeric pairs. These secondary metabolites were identified on the basis of 1D and 2D NMR including (1)H-(1)H COSY, HSQC, and HMBC spectroscopic techniques. The stereochemical configurations of compounds 4-7 were assigned through 2D T-ROESY and selective NOE experiments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Barbados
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Leonurus / chemistry*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plants, Medicinal / chemistry*

Substances

  • Diterpenes