Additional beneficial effect of tamarind ingestion over defluoridated water supply to adolescent boys in a fluorotic area

Nutrition. 2004 May;20(5):433-6. doi: 10.1016/j.nut.2004.01.007.


Objective: We evaluated the effect of tamarind (Tamarindus indicus) on ingestion and whether it provides additional beneficial effects on mobilization of fluoride from the bone after children are provided defluoridated water.

Methods: A randomized, diet control study was conducted in 30 subjects from a fluoride endemic area after significantly decreasing urinary fluoride excretion by supplying defluoridated water for 2 wk. Subjects were then assigned to one of two groups, with 15 in each group. One group was supplemented with tamarind (experimental group) for 3 wk and the other (control) group was given only defluoridated water for the same period.

Results: The mean changes in urinary components after tamarind ingestion (volume, pH, fluoride calcium, copper, and magnesium) in the control and experimental groups were compared. There was a significant increase (P < 0.01) in fluoride excretion and urinary pH and a significant decrease in urinary calcium (P < 0.01) and copper (P < 0.05) excretion in the experimental group as compared with the control group. There was no change in urinary volume between groups.

Conclusions: Tamarind intake appears to have an additional beneficial effect on the mobilization of deposited fluoride from bone, by enhancing urinary excretion of fluoride.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Dietary Supplements*
  • Fluorides / analysis
  • Fluorides / urine*
  • Fluorosis, Dental / prevention & control
  • Humans
  • Male
  • Phytotherapy*
  • Plant Preparations / administration & dosage*
  • Plant Preparations / therapeutic use
  • Tamarindus*
  • Water Pollutants, Chemical / analysis
  • Water Supply*


  • Plant Preparations
  • Water Pollutants, Chemical
  • Fluorides