Differential expression levels of MRP1, MRP4, and MRP5 in response to human immunodeficiency virus infection in human macrophages

Antimicrob Agents Chemother. 2004 May;48(5):1889-91. doi: 10.1128/AAC.48.5.1889-1891.2004.


Multidrug resistance proteins (MRPs) have been reported to be involved in the efflux of some anti-human immunodeficiency virus (HIV) drugs. We show here that MRP1, MRP4, and MRP5 are expressed at the mRNA level in human monocyte-derived macrophages. HIV infection caused increased transcription of these MRPs; however, temporal differences in stimulation are reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) / metabolism
  • HIV Infections / metabolism*
  • Humans
  • In Vitro Techniques
  • Interleukin-6 / biosynthesis
  • Macrophages / metabolism*
  • Multidrug Resistance-Associated Proteins / biosynthesis*
  • RNA, Messenger / biosynthesis
  • Reverse Transcriptase Polymerase Chain Reaction
  • Ribosomal Proteins / biosynthesis*
  • Tumor Necrosis Factor-alpha / biosynthesis


  • ABCC4 protein, human
  • ABCC5 protein, human
  • Interleukin-6
  • Multidrug Resistance-Associated Proteins
  • RNA, Messenger
  • Ribosomal Proteins
  • Tumor Necrosis Factor-alpha
  • Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+)
  • multidrug resistance-associated protein 1