General anesthesia for cesarean delivery in a patient with paroxysmal nocturnal hemoglobinuria and thrombocytopenia

Anesth Analg. 2004 May;98(5):1471-2, table of contents. doi: 10.1213/01.ane.0000108132.95279.dd.

Abstract

Pregnancy in patients with paroxysmal nocturnal hemoglobinuria (PNH) increases the risk of complement activation, hemolysis, and thrombosis. We describe the anesthetic management of a patient with PNH who underwent general anesthesia for cesarean delivery. Steroids, heparin, and blood products were administered early to minimize the likelihood of a hematologic emergency.

Implications: Pregnancy in patients with paroxysmal nocturnal hemoglobinuria increases the risk of hemolysis, thrombosis, anemia, and thrombocytopenia. We describe the anesthetic management of a patient with paroxysmal nocturnal hemoglobinuria and thrombocytopenia who underwent general anesthesia for cesarean delivery.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anesthesia, General*
  • Anesthesia, Obstetrical*
  • Cesarean Section*
  • Female
  • Hemoglobinuria, Paroxysmal / complications*
  • Hemoglobinuria, Paroxysmal / drug therapy
  • Humans
  • Male
  • Pregnancy
  • Pregnancy Outcome
  • Thrombocytopenia / complications*
  • Thrombocytopenia / prevention & control