[Effect of L-lysine-alpha-oxidase gel on development of ophthalmic herpes and herpetic skin lesions in rabbit]

I P Smirnova; S B Alekseev; V M Podboronov

[Effect of L-lysine-alpha-oxidase gel on development of ophthalmic herpes and herpetic skin lesions in rabbit]

Antibiot Khimioter. 2003;48(11):7-9.

[Article in Russian]

Authors

I P Smirnova¹, S B Alekseev, V M Podboronov

Affiliation

¹ Russian Peoples' Friendship University, Moscow. N.F. Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow.

PMID: 15106305

Abstract

The effect of various doses of L-lysine-alpha-oxidase gel (1.4-3.5 and 70 mcg/ml) on development of eye and skin herpetic lesions due to type 1 herpes simplex virus was studied on rabbits. The doses of 1.4 to 3.5 mcg/ml were not sufficient for the therapeutic effect. The dose of 70 mcg/ml provided complete healing of the lesions in 3 to 4 days. The results were confirmed by the immunological tests.

Publication types

English Abstract

MeSH terms

Amidohydrolases / administration & dosage
Amidohydrolases / therapeutic use*
Animals
Cornea / drug effects
Cornea / pathology
Dose-Response Relationship, Drug
Gels
Herpes Simplex / drug therapy*
Herpes Simplex / pathology
Herpes Zoster Ophthalmicus / drug therapy*
Herpes Zoster Ophthalmicus / pathology
Rabbits
Skin / drug effects
Skin / pathology

Substances

Gels
Amidohydrolases
L-lysine-lactamase