The talin wags the dog: new insights into integrin activation

Trends Cell Biol. 2004 Feb;14(2):55-7. doi: 10.1016/j.tcb.2003.12.009.


Integrin transmembrane receptors have a unique property that distinguishes them from other signaling receptors. Their affinity for ligands can be modulated from the inside out in response to intracellular signals generated by non-integrin receptors. Recent findings provide novel mechanistic insights into this process by demonstrating that talin, a protein that links integrins to actin, is necessary for the inside-out activation of integrins.

Publication types

  • Review

MeSH terms

  • Actin Cytoskeleton / metabolism*
  • Actin Cytoskeleton / ultrastructure
  • Animals
  • Cell Membrane / metabolism*
  • Cell Membrane / ultrastructure
  • Cytoplasm / metabolism
  • Humans
  • Integrins / metabolism*
  • Ligands
  • Protein Binding / physiology
  • Protein Conformation
  • Signal Transduction / physiology
  • Talin / metabolism*


  • Integrins
  • Ligands
  • Talin