The surfactant poloxamer-188 protects against glutamate toxicity in the rat brain

Neuroreport. 2004 Jan 19;15(1):171-4. doi: 10.1097/00001756-200401190-00033.


Membrane repair of damaged neurons by surfactant poloxamers has been noted in experimental spinal cord injury and in vitro excitotoxicity. We examined poloxamer-188 (P-188)-mediated neuroprotection in a rat model of glutamate toxicity. Quinolinate was infused into the striatum followed 10 min and 4 h later by P-188 administered either i.v. or intracisternally (i.c.), or by vehicle. Mean neuronal loss examined volumetrically 7 days later in control animals was 50% greater (P < 0.01) than after i.c. P-188 treatment; control lesion volumes were 38% greater than lesion volumes after i.v. P-188 treatment; however, that comparison did not reach significance. This robust protection against glutamate toxicity may predict P-188-mediated neuroprotection against a broad range of clinically relevant neural insults.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Brain / drug effects*
  • Brain / pathology
  • Glutamic Acid / toxicity*
  • Neuroprotective Agents / pharmacology
  • Poloxamer / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Surface-Active Agents / pharmacology*


  • Neuroprotective Agents
  • Surface-Active Agents
  • Poloxamer
  • Glutamic Acid