PZ-51 (Ebselen) in vivo protection against adriamycin-induced mouse cardiac and hepatic lipid peroxidation and toxicity

Biochem Pharmacol. 1992 Aug 18;44(4):839-41. doi: 10.1016/0006-2952(92)90427-k.

Abstract

Adriamycin (Adr)-induced cardiotoxicity occurs most likely via an oxidative mechanism of action. Moderation of this activity may result in an improved therapeutic index for this compound. PZ-51, 2-phenyl-1,2-benzoisoselenazol-3(2H)-one, is a selenoorganic compound with thiol-dependent, peroxidase-like activity. We tested this compound alone and in combination with N-acetylcysteine (NAC) for its effect on Adr-induced in vivo toxicity in Balb/c mice. These studies demonstrated that PZ-51 protects against Adr-induced lipid peroxidation in heart and liver tissue and Adr-induced toxicity in general, as measured by total serum creatine kinase activity and body weight.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetylcysteine / pharmacology
  • Animals
  • Antioxidants / pharmacology*
  • Azoles / pharmacology*
  • Body Weight / drug effects
  • Chemical and Drug Induced Liver Injury*
  • Creatine Kinase / blood
  • Doxorubicin / antagonists & inhibitors
  • Doxorubicin / toxicity*
  • Drug Interactions
  • Female
  • Heart Diseases / chemically induced*
  • Heart Diseases / prevention & control
  • Lipid Peroxidation / drug effects*
  • Liver Diseases / prevention & control
  • Mice
  • Mice, Inbred BALB C
  • Organoselenium Compounds / pharmacology*

Substances

  • Antioxidants
  • Azoles
  • Organoselenium Compounds
  • ebselen
  • Doxorubicin
  • Creatine Kinase
  • Acetylcysteine