Bcl-2: a repressor of lymphocyte death

Immunol Today. 1992 Aug;13(8):285-8. doi: 10.1016/0167-5699(92)90037-8.


The genes and mechanisms that control programmed cell death are currently the subject of intense study. The bcl-2 gene, a repressor of lymphocyte death, is perhaps the best understood of the programmed cell death associated genes. Here, Stanley Korsmeyer provides a brief overview of bcl-2, concentrating on its roles in B- and T-cell development and in oncogenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes
  • Cell Death / genetics*
  • GTP-Binding Proteins / genetics*
  • Humans
  • Lymphocyte Activation
  • Lymphoma / genetics
  • Lymphoma / immunology
  • Mice
  • Mice, Transgenic
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins c-bcl-2
  • Repressor Proteins / genetics*
  • T-Lymphocytes


  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Repressor Proteins
  • GTP-Binding Proteins