Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration

Immunol Today. 1992 Aug;13(8):291-4. doi: 10.1016/0167-5699(92)90039-A.


In this article Antal Rot calls into question the generally accepted notion that gradients of soluble chemotactic factors are responsible for leukocyte emigration from the circulation into sites of inflammation. He presents an alternative model in which chemoattractants bound to the surface of endothelial cells promote neutrophil adhesion and emigration, while soluble blood-borne attractants inhibit adhesion and emigration.

Publication types

  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Cell Adhesion / physiology
  • Cell Adhesion Molecules / physiology
  • Cell Movement / physiology
  • Endothelium, Vascular / metabolism*
  • Humans
  • Interleukin-8 / metabolism*
  • Neutrophils / physiology*


  • Cell Adhesion Molecules
  • Interleukin-8