VDJ recombination

Immunol Today. 1992 Aug;13(8):306-14. doi: 10.1016/0167-5699(92)90043-7.


The ability of lymphocyte receptor V, D and J gene segments to rearrange generates much of the receptor diversity that is the hallmark of the immune system. Naturally, the mechanisms of immunoglobulin and T-cell receptor gene recombination are of enormous interest. Here, Fred Alt and colleagues review current understanding of the process and speculate on future findings.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • DNA Nucleotidyltransferases / genetics*
  • Gene Rearrangement, T-Lymphocyte / genetics
  • Genes, Immunoglobulin*
  • Receptors, Antigen, T-Cell / genetics*
  • Recombination, Genetic
  • Substrate Specificity
  • VDJ Recombinases


  • Receptors, Antigen, T-Cell
  • DNA Nucleotidyltransferases
  • VDJ Recombinases