Antibiotic Selection Pressure and Resistance in Streptococcus Pneumoniae and Streptococcus Pyogenes

Emerg Infect Dis. 2004 Mar;10(3):514-7. doi: 10.3201/eid1003.030252.

Abstract

We correlated outpatient antibiotic use with prevalence of penicillin-nonsusceptible Streptococcus pneumoniae (PNSP), macrolide-resistant S. pneumoniae (MRSP), and macrolide-resistant S. pyogenes (MRGAS) in 20 countries. Total antibiotic use was correlated with PNSP (r = 0.75; p < 0.001), as was macrolide use with MRSP (r = 0.88; p < 0.001) and MRGAS (r = 0.71; p = 0.004). Streptococcal resistance is directly associated with antibiotic selection pressure on a national level.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Drug Resistance, Multiple, Bacterial / drug effects*
  • Europe
  • Humans
  • Penicillin Resistance
  • Practice Patterns, Physicians'
  • Prevalence
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pyogenes / drug effects*
  • United States

Substances

  • Anti-Bacterial Agents