Decreasing clinical efficacy of chloroquine in Ankazobe, Central Highlands of Madagascar

Trans R Soc Trop Med Hyg. 2004 May;98(5):311-4. doi: 10.1016/j.trstmh.2003.10.002.


The clinical efficacy of chloroquine was assessed in the Primary Health Centre of Ankazobe, Central Highlands of Madagascar. This study shows an increase in the level of chloroquine resistance with the appearance of early treatment failures and RIII resistance. Furthermore, the prevalence of clinical treatment failures is approaching the level of 25%, at which WHO recommends a change of first-line drug.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antimalarials / therapeutic use*
  • Child
  • Child, Preschool
  • Chloroquine / therapeutic use*
  • Drug Resistance
  • Female
  • Follow-Up Studies
  • Humans
  • Madagascar
  • Malaria / drug therapy*
  • Male
  • Middle Aged
  • Treatment Failure


  • Antimalarials
  • Chloroquine