Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke

Bioorg Med Chem Lett. 2004 May 17;14(10):2685-91. doi: 10.1016/j.bmcl.2003.12.106.

Abstract

Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described herein.

MeSH terms

  • Apoptosis / drug effects
  • Carbamates
  • Caspase Inhibitors*
  • Cell Line
  • Dipeptides / chemical synthesis*
  • Dipeptides / pharmacology*
  • Humans
  • Inhibitory Concentration 50
  • Kinetics
  • Neurodegenerative Diseases / drug therapy
  • Stroke / drug therapy
  • Structure-Activity Relationship

Substances

  • Carbamates
  • Caspase Inhibitors
  • Dipeptides
  • oxamyl