CARDINAL roles in apoptosis and NFkappaB activation

Vitam Horm. 2004:67:133-47. doi: 10.1016/S0083-6729(04)67008-7.


Numerous proteins containing the caspase recruitment domain (CARD) have now been identified. While certain CARD-containing proteins are involved in caspase activation in the context of apoptosis, many others participate in NFkappaB signaling pathways associated with innate or adaptive immune responses. Here, we discuss the CARD-containing proteins that have been implicated as participants in immune response signaling pathways that culminate in NFkappaB activation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Animals
  • Apoptosis*
  • CARD Signaling Adaptor Proteins
  • Carrier Proteins / physiology*
  • Caspase 1 / metabolism
  • Humans
  • Inflammation
  • NF-kappa B / physiology*
  • Neoplasm Proteins / physiology*


  • Adaptor Proteins, Signal Transducing
  • CARD Signaling Adaptor Proteins
  • CARD8 protein, human
  • Carrier Proteins
  • NF-kappa B
  • Neoplasm Proteins
  • Caspase 1