Coccidiosis Control by Administering Toltrazuril in the Drinking Water for a 2-day Period

Vet Parasitol. 2004 May 7;121(1-2):1-9. doi: 10.1016/j.vetpar.2004.02.020.


A 56-day floor pen study was conducted to determine the appropriate time to administer toltrazuril (Baycox) (TOL) for control of coccidiosis in broiler chickens. Litter was seeded with field strains of Eimeria acervulina, Eimeria maxima and Eimeria tenella. On Days 0, 21, 35 and 56, all birds and feed were weighed. Starting on Day 14, weekly lesion scores and oocyst counts were performed. The treatments were 125 ppm nicarb (NIC) in the starter to 66 ppm salinomycin (SAL) in the grower with no TOL (NIC/SAL/no TOL), 66 ppm salinomycin in both the starter and the grower but no TOL (SAL/SAL/no TOL), or no in-feed medication with the following TOL treatment: TOL Days 2-3, TOL Days 6-7, TOL Days 10-11, TOL Days 14-15, TOL Days 18-19, and as control NM/NM/no TOL (NM). The withdrawal feed was nonmedicated. TOL was administered in the drinking water at the rate of 7 mg/kg body weight. Oocysts per gram litter and lesion scores showed a significant infection in the NM birds, which peaked about Day 21. The NIC/SAL gave excellent early protection but only moderate protection during the SAL phase. The final performance for the SAL/SAL was significantly less compared to all TOL and NIC/SAL birds. All TOL treatments but Days 2-3 provided good coccidiosis control with accompanying performance. The absence of clinical coccidiosis relapse during the last third of the growout along with moderate oocyst counts and low lesions was indicative of unimpaired coccidiosis immunity. It can be inferred from the overall results that the use of TOL as the sole anticoccidial for two consecutive days in the drinking water between Days 10 and 14 would be the best time for good coccidiosis control allowing full performance.

MeSH terms

  • Animals
  • Body Weight / drug effects
  • Chickens*
  • Coccidiosis / parasitology
  • Coccidiosis / pathology
  • Coccidiosis / prevention & control*
  • Coccidiosis / veterinary*
  • Coccidiostats / administration & dosage*
  • Eimeria / metabolism*
  • Feces / parasitology
  • Intestines / parasitology
  • Male
  • Nicarbazin / administration & dosage
  • Parasite Egg Count / veterinary
  • Poultry Diseases / parasitology*
  • Poultry Diseases / prevention & control*
  • Pyrans / administration & dosage
  • Random Allocation
  • Triazines / administration & dosage*


  • Coccidiostats
  • Pyrans
  • Triazines
  • Nicarbazin
  • salinomycin
  • toltrazuril