Sablacaurin A and B, two 19-nor-3,4-seco-lanostane-type triterpenoids from Sabal causiarum and Sabal blackburniana, respectively

Rabab El-Dib; Maki Kaloga; Ibrahim Mahmoud; Hesham S M Soliman; Fatma A Moharram; Herbert Kolodziej

doi:10.1016/j.phytochem.2004.02.026

Sablacaurin A and B, two 19-nor-3,4-seco-lanostane-type triterpenoids from Sabal causiarum and Sabal blackburniana, respectively

Phytochemistry. 2004 Apr;65(8):1153-7. doi: 10.1016/j.phytochem.2004.02.026.

Authors

Rabab El-Dib¹, Maki Kaloga, Ibrahim Mahmoud, Hesham S M Soliman, Fatma A Moharram, Herbert Kolodziej

Affiliation

¹ Freie Universität Berlin, Institut für Pharmazie, Pharmazeutische Biologie, Königin-Luise-Str. 2+4, D-14195 Berlin, Germany.

PMID: 15110697
DOI: 10.1016/j.phytochem.2004.02.026

Abstract

In search for bioactive compounds from Sabal species, sablacaurin A [25-ethyl,23-methyl-19-nor-24-methylene-3,4-seco-4(28)-lanosten-10,3-olide] and sablacaurin B [24-ethyl,24-methyl-19-nor-3,4-seco-4(28),25(26)-lanostadiene-10,3-olide], the first 19-nor lanostane derivatives of the 3,4-seco type with a spiro element, have been isolated from the leaves of Sabal causiarum and Sabal blackburniana respectively, together with the known squalene (S. blackburniana) and ss-sitosterol (S. causiarum). From leaves of Sabal peregrina, the known triterpenes 3-oxo-24-methylenecycloartane and 24-methylcycloart-25(26)-en-3-one were isolated. The structures of these compounds were established from spectroscopic studies.

MeSH terms

Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Leaves / chemistry
Serenoa / chemistry*
Triterpenes / chemistry*
Triterpenes / isolation & purification

Substances

Triterpenes