Synthesis and Structure Activity Relationship of Guanidines as NPY Y5 Antagonists

Bioorg Med Chem. 2004 May 15;12(10):2691-708. doi: 10.1016/j.bmc.2004.03.012.

Abstract

A series of bis-aryl substituted guanidines have been discovered as potent NPY Y5 antagonists. The SAR and in vitro metabolic stability of these compounds are discussed.

MeSH terms

  • Animals
  • CHO Cells
  • Cricetinae
  • Cricetulus
  • Guanidines / chemical synthesis*
  • Guanidines / chemistry
  • Guanidines / pharmacology*
  • Molecular Structure
  • Radioligand Assay
  • Receptors, Neuropeptide Y / antagonists & inhibitors*
  • Structure-Activity Relationship

Substances

  • Guanidines
  • Receptors, Neuropeptide Y
  • neuropeptide Y5 receptor