Nimodipine for Treatment of Primary Thunderclap Headache

Neurology. 2004 Apr 27;62(8):1414-6. doi: 10.1212/01.wnl.0000120669.85649.77.

Abstract

Eleven patients with primary thunderclap headache (TCH) were treated with oral nimodipine 30 to 60 mg every 4 hours or IV nimodipine 0.5 to 2 mg/h if the oral regimen failed or images showed cerebral vasospasm. With oral nimodipine, headache did not recur in the nine patients without vasospasm. IV nimodipine was given in two patients with vasospasm, including one who developed ischemic stroke. Nimodipine may be effective for TCH. Vasospasm may warrant IV nimodipine.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Brain / blood supply
  • Brain / diagnostic imaging
  • Cerebral Angiography
  • Female
  • Headache / complications
  • Headache / diagnosis
  • Headache / drug therapy*
  • Headache / prevention & control
  • Humans
  • Injections, Intravenous
  • Magnetic Resonance Angiography
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Nimodipine / administration & dosage
  • Nimodipine / therapeutic use*
  • Treatment Outcome
  • Vasodilator Agents / administration & dosage
  • Vasodilator Agents / therapeutic use*
  • Vasospasm, Intracranial / complications
  • Vasospasm, Intracranial / diagnosis
  • Vasospasm, Intracranial / drug therapy*

Substances

  • Vasodilator Agents
  • Nimodipine