Measurement error of two different techniques for brain atrophy assessment in multiple sclerosis

Neurology. 2004 Apr 27;62(8):1432-4. doi: 10.1212/01.wnl.0000120663.85143.b3.


The measurement errors associated with two techniques for brain atrophy assessment in multiple sclerosis (MS) were estimated. The measurement error of a semiautomated, nonnormalized technique with partial brain coverage was about twofold higher than that of a fully automated, normalized technique with full brain coverage (Structural Image Evaluation of Normalized Atrophy software [SIENA]). As shown by the analysis of data from a clinical trial of glatiramer acetate, the use of SIENA increases the study power to detect a treatment effect on brain volume changes in MS patients.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Atrophy / complications
  • Atrophy / diagnosis*
  • Atrophy / drug therapy
  • Brain / pathology*
  • Brain Diseases / complications
  • Brain Diseases / diagnosis*
  • Brain Diseases / drug therapy
  • Double-Blind Method
  • Glatiramer Acetate
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Imaging / statistics & numerical data*
  • Multiple Sclerosis / complications*
  • Multiple Sclerosis / drug therapy
  • Peptides / therapeutic use
  • Predictive Value of Tests
  • Randomized Controlled Trials as Topic / statistics & numerical data
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Statistics as Topic / methods


  • Immunosuppressive Agents
  • Peptides
  • Glatiramer Acetate