Expression and significance of angiopoietin-2 in gastric cancer

World J Gastroenterol. 2004 May 1;10(9):1382-5. doi: 10.3748/wjg.v10.i9.1382.


Aim: To investigate the expression and pathological factors of Angiopoietin-2 (Ang-2) in primary gastric cancers and adjacent normal tissues.

Methods: The expression of Angiopoietin-2 and VEGF were studied in 72 primary gastric cancers and adjacent normal tissues from the same patients by semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry.

Results: Ang-2 was mainly expression in tumor cells. There were significantly difference between expression of Ang-2 in primary gastric cancer and in adjacent normal tissue samples (P=0.003). It was statistically correlation between Ang-2 and VEGF expression in tumors (P=0.0055). With regard to Ang-2 expression in tumors, there were significant difference between early stage and advanced stage (P=0.017), and significant difference between positive vascular involvement and negative vascular involvement (P=0.032). However, there was no significant difference between moderate-poor differential type and high differential type (P=0.908), between positive lymph node metastasis and negative lymph node metastasis (P=0.752), between positive serosal invasion and negative serosal invasion (P=0.764). The cases with expression of Ang-2 were increasing with advanced stage and vascular involvement.

Conclusion: The results manifested that Angiopoietin-2, coordinated with VEGF, play role in regulating tumor angiogenesis of gastric cancer.

MeSH terms

  • Adult
  • Aged
  • Angiopoietin-2 / genetics
  • Angiopoietin-2 / metabolism*
  • Female
  • Gastric Mucosa / cytology
  • Gastric Mucosa / metabolism
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Reverse Transcriptase Polymerase Chain Reaction
  • Statistics as Topic
  • Stomach Neoplasms / metabolism*
  • Stomach Neoplasms / pathology
  • Vascular Endothelial Growth Factor A / genetics
  • Vascular Endothelial Growth Factor A / metabolism


  • Angiopoietin-2
  • Vascular Endothelial Growth Factor A