Controlled-release oxycodone for the management of pediatric postoperative pain

J Pain Symptom Manage. 2004 Apr;27(4):379-86. doi: 10.1016/j.jpainsymman.2003.08.007.


Studies addressing pain management after pediatric spinal fusion surgery have focused on the use of patient-controlled or epidural analgesia during the immediate postoperative period. Controlled-release (CR) analgesics have been found to be safe and effective in adults. The purpose of this study was to describe the use of oxycodone-CR in pediatric patients after the immediate postoperative period. A retrospective chart review of 62 postoperative spinal fusion patients (10-19 years) was conducted. The mean initial oxycodone-CR dose was 1.24 mg/kg/day. The mean ratio of conversion from parenteral morphine equivalents to oxycodone-CR was 1:1. Mean pain scores decreased from 4.2/10 to 3.7/10 with the transition to oxycodone-CR. Common side effects included dizziness, constipation, and nausea. Oxycodone-CR was used for an average of 13.3 days, which included an average wean time of 6 days. Results of this study demonstrate safe and effective use of oxycodone-CR in the pediatric spinal fusion population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Analgesics, Opioid / administration & dosage*
  • Analgesics, Opioid / adverse effects
  • Child
  • Delayed-Action Preparations
  • Female
  • Humans
  • Male
  • Oxycodone / administration & dosage*
  • Oxycodone / adverse effects
  • Pain, Postoperative / drug therapy*
  • Retrospective Studies
  • Treatment Outcome


  • Analgesics, Opioid
  • Delayed-Action Preparations
  • Oxycodone