Targeting FOXO kills two birds with one stone

Chem Biol. 2004 Jan;11(1):16-8. doi: 10.1016/j.chembiol.2004.01.011.

Abstract

PTEN deficiency activates Akt signaling and results in a variety of human malignancies. Encouragingly, recent studies demonstrate that small molecules can regulate FOXO1a, an Akt target, to suppress tumor growth, and FOXO1a is therefore a promising anticancer drug target.

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • DNA-Binding Proteins / pharmacology*
  • Forkhead Box Protein O1
  • Forkhead Transcription Factors
  • Humans
  • Protein-Serine-Threonine Kinases / drug effects
  • Protein-Serine-Threonine Kinases / physiology
  • Proto-Oncogene Proteins / drug effects
  • Proto-Oncogene Proteins / physiology
  • Proto-Oncogene Proteins c-akt
  • Signal Transduction / drug effects
  • Transcription Factors / pharmacology*
  • Tumor Suppressor Proteins / physiology

Substances

  • Antineoplastic Agents
  • DNA-Binding Proteins
  • FOXO1 protein, human
  • Forkhead Box Protein O1
  • Forkhead Transcription Factors
  • Proto-Oncogene Proteins
  • Transcription Factors
  • Tumor Suppressor Proteins
  • AKT1 protein, human
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt