Ammonia: a possible promotor in Helicobacter pylori-related gastric carcinogenesis

Cancer Lett. 1992 Jul 31;65(1):15-8. doi: 10.1016/0304-3835(92)90207-c.


Helicobacter pylori (HP) has been shown to possibly be a pathogen of gastric carcinoma. HP has urease activity and produces ammonia in the stomach. In this study, the role of ammonia on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were investigated in rats. After 24 weeks pretreatment with MNNG (83 mg/l), 0.01% ammonia or tap water as a drinking water was administered for 24 weeks. The ammonia-treated rats showed a significantly higher incidence of gastric cancer (percent of animals with tumors and number of tumors per rat). Ammonia would thus appear to have an important role in HP-related human gastric carcinogenesis.

MeSH terms

  • Adenocarcinoma / chemically induced*
  • Administration, Oral
  • Ammonia / toxicity*
  • Animals
  • Cell Transformation, Neoplastic
  • Helicobacter pylori / pathogenicity
  • Male
  • Methylnitronitrosoguanidine
  • Rats
  • Rats, Inbred Strains
  • Stomach Neoplasms / chemically induced*


  • Methylnitronitrosoguanidine
  • Ammonia