Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats

J Med Food. Spring 2004;7(1):61-6. doi: 10.1089/109662004322984725.


In the present study an attempt has been made to evaluate the presence of hypoglycemic activity in the alcoholic extract of Aloe vera gel. Effects of oral administration of A. vera extract at a concentration of 200 and 300 mg/kg of body weight on (a) normal fasted rats, (b) oral glucose-loaded rats, and (c) streptozotocin-induced diabetic rats have been studied. A. vera extract maintain the glucose homeostasis by controlling the carbohydrate metabolizing enzymes.

MeSH terms

  • Administration, Oral
  • Aloe* / chemistry
  • Animals
  • Blood Glucose / drug effects
  • Blood Glucose / metabolism*
  • Diabetes Mellitus, Experimental / drug therapy*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Gels
  • Hypoglycemic Agents / therapeutic use*
  • Male
  • Phytotherapy*
  • Plant Extracts / therapeutic use*
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Streptozocin


  • Blood Glucose
  • Gels
  • Hypoglycemic Agents
  • Plant Extracts
  • Streptozocin