Efficacy of risedronate on clinical vertebral fractures within six months

Curr Med Res Opin. 2004 Apr;20(4):433-9. doi: 10.1185/030079903125003125.


Objective: Postmenopausal osteoporotic women with pre-existing or new incident vertebral fractures are at high risk for future fracture, so prompt treatment is warranted. Risedronate has been shown to reduce the incidence of radiographically-defined vertebral fractures by approximately two-thirds within 1 year.

Research design: This study examined the effects of risedronate treatment on the time course of the reduction in the risk of clinical vertebral fractures (i.e., symptomatic fractures), on the risk of moderate-to-severe radiographic vertebral fractures, and on height.

Results: In 2442 postmenopausal women with prevalent vertebral fractures from the Vertebral Efficacy with Risedronate Therapy (VERT) studies who received either risedronate 5 mg or placebo, daily risedronate reduced the risk of clinical vertebral fractures within 6 months (RR = 0.08, 95% CI 0.01-0.63), and by 69% at 1 year (RR = 0.31, 95% CI 0.12, 0.78). At 1 year, risedronate also reduced the risk of moderate-to-severe radiographically-defined vertebral fractures by 71% (RR = 0.29 95% CI 0.16, 0.54). Height loss was attenuated with treatment, most notably in patients who experienced new vertebral fractures, with a median difference of 0.73 cm compared with subjects receiving placebo (p = 0.005).

Conclusion: Risedronate reduces the risk of clinical vertebral fractures in postmenopausal women with osteoporosis within 6 months of commencing treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Body Height
  • Etidronic Acid / analogs & derivatives*
  • Etidronic Acid / therapeutic use*
  • Female
  • Fractures, Spontaneous / diagnostic imaging
  • Fractures, Spontaneous / etiology
  • Fractures, Spontaneous / prevention & control*
  • Humans
  • Osteoporosis, Postmenopausal / drug therapy*
  • Radiography
  • Randomized Controlled Trials as Topic
  • Risedronic Acid
  • Spinal Fractures / diagnostic imaging
  • Spinal Fractures / etiology
  • Spinal Fractures / prevention & control*


  • Risedronic Acid
  • Etidronic Acid