Nodal signaling: CrypticLefty mechanism of antagonism decoded

Curr Biol. 2004 May 4;14(9):R341-3. doi: 10.1016/j.cub.2004.04.020.

Abstract

The secreted TGFbeta factor Lefty antagonizes Nodal signaling during vertebrate embryogenesis, but how it does so has been a mystery. Recent analyses have elucidated the molecular mechanisms underlying this function of Lefty.

Publication types

  • Review

MeSH terms

  • Animals
  • Epidermal Growth Factor / metabolism
  • Glycoproteins / metabolism
  • Left-Right Determination Factors
  • Nodal Protein
  • Signal Transduction / physiology*
  • Transforming Growth Factor beta / antagonists & inhibitors*
  • Transforming Growth Factor beta / metabolism*
  • Transforming Growth Factor beta / physiology
  • Vertebrates / embryology*

Substances

  • Glycoproteins
  • Left-Right Determination Factors
  • Nodal Protein
  • Transforming Growth Factor beta
  • Epidermal Growth Factor