Mitosis: MCAK under the aura of Aurora B

Curr Biol. 2004 May 4;14(9):R346-8. doi: 10.1016/j.cub.2004.04.022.

Abstract

Two new studies show that phosphorylation by Aurora B kinase controls the centromere localization and catalytic activity of the microtubule depolymerase MCAK. Physical tension from microtubule attachment may influence access of MCAK to Aurora B kinase and its opposing phosphatases.

Publication types

  • Review

MeSH terms

  • Aurora Kinase B
  • Aurora Kinases
  • Catalysis
  • Centromere / physiology*
  • Kinesin / metabolism*
  • Kinesin / physiology
  • Microtubules / metabolism*
  • Microtubules / physiology
  • Mitosis / physiology*
  • Models, Biological
  • Phosphorylation
  • Protein-Serine-Threonine Kinases / metabolism*
  • Protein-Serine-Threonine Kinases / physiology

Substances

  • KIF2C protein, human
  • AURKB protein, human
  • Aurora Kinase B
  • Aurora Kinases
  • Protein-Serine-Threonine Kinases
  • Kinesin