Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells

Lancet. 2004 May 1;363(9419):1439-41. doi: 10.1016/S0140-6736(04)16104-7.

Abstract

Adult bone-marrow-derived mesenchymal stem cells are immunosuppressive and prolong the rejection of mismatched skin grafts in animals. We transplanted haploidentical mesenchymal stem cells in a patient with severe treatment-resistant grade IV acute graft-versus-host disease of the gut and liver. Clinical response was striking. The patient is now well after 1 year. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adult
  • Child
  • Chromosomes, Human, X
  • Chromosomes, Human, Y
  • Female
  • Graft vs Host Disease / therapy*
  • Haploidy
  • Humans
  • Immunosuppression
  • In Situ Hybridization, Fluorescence
  • Intestinal Mucosa / ultrastructure
  • Lymphocyte Culture Test, Mixed
  • Male
  • Mesenchymal Stem Cell Transplantation*
  • Mesenchymal Stem Cells / immunology
  • Transplantation Chimera
  • Transplantation, Homologous