Two regimens of misoprostol for treatment of incomplete abortion

Obstet Gynecol. 2004 May;103(5 Pt 1):860-5. doi: 10.1097/01.AOG.0000124274.47717.a7.


Objectives: Misoprostol shows promise for treatment of incomplete abortion. We evaluated 2 simple misoprostol regimens to estimate whether they were effective in treating incomplete abortion.

Methods: A total of 169 women was randomly assigned to either a single or double dose of 600 microg misoprostol. The women, who would have received a surgical evacuation of the uterus for incomplete abortion, were patients at 2 hospitals in Bangkok, Thailand. The 2 groups of women were compared for success of treatment (no need for surgical evacuation), side effects, and acceptability.

Results: Sixty-six percent of women in the single-dose group and 70% of women in the double-dose group had complete abortions with misoprostol. More than 90% of women in the single- and double-dose groups reported that the side effects were tolerable; frequency of side effects was similar between the 2 groups. Women found the treatment acceptable. Approximately 90% of women in both groups would recommend the treatment to a friend. Acceptability and efficacy were different at the 2 participating clinics.

Conclusion: Misoprostol is an effective treatment for incomplete abortion. Simple regimens may be as effective as more complicated ones and a single dose of 600 microg should be further evaluated in larger trials.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Abortifacient Agents, Nonsteroidal / administration & dosage*
  • Abortifacient Agents, Nonsteroidal / adverse effects
  • Abortion, Incomplete / drug therapy*
  • Administration, Oral
  • Adult
  • Female
  • Humans
  • Misoprostol / administration & dosage*
  • Misoprostol / adverse effects
  • Pregnancy


  • Abortifacient Agents, Nonsteroidal
  • Misoprostol