Dendritic cell immunotherapy: mapping the way

Nat Med. 2004 May;10(5):475-80. doi: 10.1038/nm1039.

Abstract

Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system, with the potential to either stimulate or inhibit immune responses. Exploiting the immune-regulatory capacities of dendritic cells holds great promise for the treatment of cancer, autoimmune diseases and the prevention of transplant rejection. Although early clinical trials indicate that DC vaccines can induce immune responses in some cancer patients, careful study design and use of standardized clinical and immunological criteria are needed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens / administration & dosage
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / therapy
  • Cancer Vaccines / isolation & purification
  • Cancer Vaccines / standards
  • Clinical Trials as Topic / methods
  • Dendritic Cells / immunology*
  • Humans
  • Immunosuppression / methods
  • Immunotherapy / methods*
  • In Vitro Techniques
  • Neoplasms / immunology
  • Neoplasms / therapy

Substances

  • Antigens
  • Cancer Vaccines