RNA: primed for packing?

Chem Biol. 2004 Feb;11(2):149-51. doi: 10.1016/j.chembiol.2004.02.007.


How does RNA's seemingly subtle 2'-hydroxyl group contribute to its diverse biological functions? Using quantitative structure-activity relationship (QSAR) analysis, Piccirilli and colleagues find that the 2'-OH fosters van der Waals and hydrophobic interactions that play underappreciated roles in RNA structure and molecular recognition.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Hydroxyl Radical
  • RNA / chemistry*
  • RNA / metabolism
  • RNA / physiology*
  • Structure-Activity Relationship


  • Hydroxyl Radical
  • RNA