Hypoadiponectinemia is an independent risk factor for hypertension

Hypertension. 2004 Jun;43(6):1318-23. doi: 10.1161/01.HYP.0000129281.03801.4b. Epub 2004 May 3.


Adiponectin is one of the key molecules in the metabolic syndrome, and its concentration is decreased in obesity, type-2 diabetes, and coronary artery disease. Genetic investigation has revealed that 2 polymorphisms (I164T and G276T) are related to adiponectin concentration and diabetes. To examine whether adiponectin affects hypertension genetically or biologically, we performed a case-control study. A total of 446 diagnosed cases of hypertension (HT) in men and 312 normotensive (NT) men were enrolled in this study. Plasma adiponectin concentration was measured using an enzyme-linked immunosorbent assay system. Single nucleotide polymorphisms were determined by TaqMan polymerase chain reaction method. After adjustment for confounding factors, adiponectin concentration was significantly lower in HT (HT: 5.2+/-0.2 microg/mL; NT: 6.1+/-0.2 microg/mL; P<0.001). Furthermore, multiple regression analysis indicated that hypoadiponectinemia was an independent risk factor for hypertension (P<0.001). Blood pressure was inversely associated with adiponectin concentration in normotensives regardless of insulin resistance. In subjects carrying the TC genotype of the I164T polymorphism, adiponectin concentration was significantly lower (TC: 2.6+/-0.9 microg/mL; TT: 5.5+/-0.1 microg/mL; P<0.01), and most of them had hypertension. In contrast, the G276T polymorphism was not associated with adiponectin concentration or hypertension. In conclusion, hypoadiponectinemia is a marker for predisposition to hypertension in men.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin
  • Amino Acid Substitution*
  • Case-Control Studies
  • Creatinine / blood
  • Cross-Sectional Studies
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Hypertension / blood*
  • Hypertension / epidemiology
  • Insulin Resistance / genetics*
  • Intercellular Signaling Peptides and Proteins*
  • Japan / epidemiology
  • Lipids / blood
  • Male
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / epidemiology
  • Metabolic Syndrome / genetics
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Proteins / analysis*
  • Proteins / genetics
  • Risk Factors


  • Adiponectin
  • Intercellular Signaling Peptides and Proteins
  • Lipids
  • Proteins
  • Creatinine