Metformin attenuates progression of carotid arterial wall thickness in patients with type 2 diabetes

Diabetes Res Clin Pract. 2004 Jun;64(3):225-8. doi: 10.1016/j.diabres.2003.11.007.

Abstract

To investigate the anti-atherogenic effect of metformin, we prospectively evaluated the effect of metformin treatment on common carotid intima-media thickness (CCA-IMT) in patients with type 2 diabetes. A 2-year open prospective study was performed. Thirty-six patients were treated with metformin (500-750 mg per day). CCA-IMT was measured after 1- and 2-year treatment. Changes in CCA-IMT were compared with control patients. After 2-year metformin therapy, the progression of CCA-IMT was significantly less than 56 control patients (0.02+/-0.08 mm versus 0.07+/-0.08 mm, P<0.01). Metformin therapy did not alter body weight, blood pressure, HbA1c, and serum lipids relative to the control. Thus, metformin attenuates the progression of CCA-IMT. This anti-atherogenic effect is not mediated through changes in classical cardiovascular risk factors.

Publication types

  • Comparative Study

MeSH terms

  • Arteriosclerosis / complications
  • Arteriosclerosis / drug therapy
  • Arteriosclerosis / prevention & control
  • Carotid Arteries / drug effects*
  • Carotid Arteries / pathology
  • Carotid Arteries / physiology
  • Carotid Artery Diseases / complications
  • Carotid Artery Diseases / drug therapy
  • Chronic Disease
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Diabetes Mellitus, Type 2 / pathology
  • Diet Therapy
  • Drug Administration Schedule
  • Female
  • Gliclazide / therapeutic use
  • Glyburide / therapeutic use
  • Glycated Hemoglobin A / chemistry
  • Glycated Hemoglobin A / drug effects
  • Glycated Hemoglobin A / physiology
  • Humans
  • Japan
  • Male
  • Metformin / pharmacology
  • Metformin / therapeutic use*
  • Middle Aged
  • Prospective Studies
  • Sulfonylurea Compounds / therapeutic use
  • Time Factors
  • Tunica Intima / drug effects*
  • Tunica Intima / pathology
  • Tunica Intima / physiology
  • Tunica Media / drug effects*
  • Tunica Media / pathology
  • Tunica Media / physiology

Substances

  • Glycated Hemoglobin A
  • Sulfonylurea Compounds
  • glimepiride
  • Metformin
  • Gliclazide
  • Glyburide