Progressive beta cell failure in type 2 diabetes mellitus of youth

J Pediatr. 2004 May;144(5):656-9. doi: 10.1016/j.jpeds.2003.12.045.


The pathophysiology of type 2 diabetes mellitus (T2DM) involves insulin resistance and insulin deficiency. We report the progression in insulin sensitivity and secretion over a 6-year period in an adolescent with T2DM. This report further demonstrates that the earliest abnormality in youth T2DM is insulin resistance followed by progressive beta-cell failure.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Child
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Disease Progression
  • Female
  • Humans
  • Insulin Resistance
  • Islets of Langerhans / physiopathology*