Frequency of reduced vancomycin susceptibility and heterogeneous subpopulation in persistent or recurrent methicillin-resistant Staphylococcus aureus bacteremia

Clin Infect Dis. 2004 May 1;38(9):1328-30. doi: 10.1086/383036. Epub 2004 Apr 14.


Vancomycin susceptibility was checked in isolates from initial and final blood samples obtained from 22 patients with persistent or recurrent methicillin-resistant Staphylococcus aureus bacteremia. The minimum inhibitory concentration of vancomycin was determined using Etest and found to have increased in 2 pairs of isolates, and results of screening in 4 mu g vancomycin and a modified population analysis profile suggested heteroresistance in 3 isolates (13.6%). Heteroresistance is not a common cause of persistent or recurrent bacteremia.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacteremia / microbiology*
  • Drug Resistance, Multiple
  • Humans
  • Methicillin Resistance*
  • Microbial Sensitivity Tests
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus / drug effects*
  • Vancomycin / pharmacology*
  • Vancomycin Resistance


  • Anti-Bacterial Agents
  • Vancomycin