Report on the incidence of interstitial lung diseases in Spain

Sarcoidosis Vasc Diffuse Lung Dis. 2004 Mar;21(1):64-70.


Background and aim of the work: Almost no epidemiological data are available on a worldwide basis on the prevalence, incidence or relative frequency of interstitial lung diseases (ILD). We report the results of a registration of ILD by 23 centers of pulmonary medicine in Spain over one year (from October 2000 to September 2001).

Methods: A standardized questionnaire was sent to the centers, together with guidelines for classification and diagnostic evaluation. This questionnaire included questions about the explorations performed to establish the diagnosis.

Results: A total of 511 cases were registered. The mean age of the patients was 61 +/- 0.7 (x +/- SEM) yrs. The male to female ratio was 1.2:1. The estimated incidence of ILD was 7.6 per 100,000/year. The most frequent disease was idiopathic pulmonary fibrosis (38.6%), followed in decreasing order by sarcoidosis (14.9%), cryptogenic organizing pneumonia (10.4%), ILD associated with collagen vascular diseases (9.9%) and hypersensitivity pneumonitis (6.6%). In 5.1% of cases ILD was unclassified. HRCT scan was performed in 91.9% of cases, bronchoalveolar lavage in 67.9%, transbronchial lung biopsy in 59.9%, and surgical lung biopsy in 22.7%.

Conclusions: This registration provides interesting information on the occurrence of ILD in Spain and on the procedures used to establish the diagnosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Epidemiologic Studies
  • Female
  • Health Surveys
  • Humans
  • Lung Diseases, Interstitial / epidemiology*
  • Male
  • Middle Aged
  • Reference Values
  • Registries / statistics & numerical data*
  • Spain / epidemiology