Enantioselective synthesis of allylic alcohols by the sequential aminoxylation-olefination reactions of aldehydes under ambient conditions

Guofu Zhong; Yongping Yu

doi:10.1021/ol049524k

Enantioselective synthesis of allylic alcohols by the sequential aminoxylation-olefination reactions of aldehydes under ambient conditions

Org Lett. 2004 May 13;6(10):1637-9. doi: 10.1021/ol049524k.

Authors

Guofu Zhong¹, Yongping Yu

Affiliation

¹ Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. gzhong@scripps.edu

PMID: 15128255
DOI: 10.1021/ol049524k

Abstract

A novel, highly enantioselective synthesis of O-amino-substituted allylic alcohols by the sequential asymmetric alpha-aminoxylation/Wadsworth-Emmons-Horner olefination reactions of aldehydes is presented.