Orthologous gene-expression profiling in multi-species models: search for candidate genes

Genome Biol. 2004;5(5):R34. doi: 10.1186/gb-2004-5-5-r34. Epub 2004 Apr 27.


Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Line
  • Disease Models, Animal
  • Dogs
  • Endothelium / chemistry
  • Endothelium / cytology
  • Endothelium / metabolism
  • Gene Expression Profiling / methods*
  • Gene Expression Profiling / statistics & numerical data
  • Genes / genetics
  • Humans
  • Lung / chemistry
  • Lung / metabolism
  • Lung Diseases / genetics
  • Mice
  • Models, Genetic*
  • Oligonucleotide Array Sequence Analysis / methods*
  • Oligonucleotide Array Sequence Analysis / statistics & numerical data
  • Rats
  • Species Specificity