Role of T cell costimulation in anti-viral immunity

Semin Immunol. 2004 Jun;16(3):185-96. doi: 10.1016/j.smim.2004.02.006.


Members of both the CD28 and TNFR families can have costimulatory roles in T cell activation. Gene targeted mice as well as in vivo blocking experiments have established distinct roles for CD28/B7; ICOS/ICOSL; CD27/CD70; 4-1BB/4-1BBL and OX40/OX40L during viral infection. Many issues remain to be addressed, including the timing and location of the interactions, the possibility of partial redundancy between related family members and the molecular basis for the specific phenotypes observed in the different gene targeted mice.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD / immunology
  • Antigens, Differentiation, T-Lymphocyte / immunology
  • CD27 Ligand
  • Inducible T-Cell Co-Stimulator Protein
  • Ligands
  • Lymphocyte Activation*
  • Membrane Proteins / immunology
  • Mice
  • Receptors, Cell Surface / immunology
  • Receptors, Nerve Growth Factor / immunology
  • Receptors, Tumor Necrosis Factor / immunology
  • T-Lymphocytes / immunology*
  • Tumor Necrosis Factor Receptor Superfamily, Member 9
  • Virus Diseases / immunology*


  • Antigens, CD
  • Antigens, Differentiation, T-Lymphocyte
  • CD27 Ligand
  • Cd70 protein, mouse
  • Icos protein, mouse
  • Inducible T-Cell Co-Stimulator Protein
  • Ligands
  • Membrane Proteins
  • Receptors, Cell Surface
  • Receptors, Nerve Growth Factor
  • Receptors, Tumor Necrosis Factor
  • Tnfrsf9 protein, mouse
  • Tumor Necrosis Factor Receptor Superfamily, Member 9