O-GlcNAc modification: a nutritional sensor that modulates proteasome function

Trends Cell Biol. 2004 May;14(5):218-21. doi: 10.1016/j.tcb.2004.03.005.


The addition of O-linked beta-N-acetylglucosamine (O-GlcNAc) to serine and threonine residues is a post-translational modification of nucleocytoplasmic proteins that is thought to act in a manner analogous to protein phosphorylation. Recent work shows that many proteins of the metazoan proteasome are modified by O-GlcNAc and that the level of glycosylation is responsive to the nutritional state of the cell. Moreover, increased glycosylation of the 19S (or PA700) regulatory subcomplex has been correlated with decreased proteasomal activity, suggesting a new model of proteasomal regulation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetylglucosamine / chemistry
  • Acetylglucosamine / metabolism*
  • Animals
  • Drosophila / enzymology
  • Drosophila / metabolism
  • Humans
  • Nutritional Physiological Phenomena / physiology*
  • Proteasome Endopeptidase Complex / chemistry*
  • Proteasome Endopeptidase Complex / metabolism*
  • Proteomics


  • Proteasome Endopeptidase Complex
  • Acetylglucosamine