Modeling diabetic sensory neuropathy in rats

Methods Mol Med. 2004;99:55-65. doi: 10.1385/1-59259-770-x:225.


The procedures to induce insulin-deficient diabetes in rats using streptozotocin are described along with a number of insulin treatment regimes that can be used to maintain these animals at different degrees of glycemia for periods of weeks to months. Streptozotocin-diabetic rats develop tactile allodynia, hyperalgesia following paw formalin injection and abnormal responses to thermal stimulation and the detailed methods used to evaluate these behavioral indices of abnormal sensory function are provided.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Diabetes Mellitus, Experimental / drug therapy
  • Diabetes Mellitus, Experimental / physiopathology*
  • Diabetic Neuropathies / drug therapy
  • Diabetic Neuropathies / physiopathology*
  • Disease Models, Animal*
  • Female
  • Insulin / therapeutic use
  • Pain Measurement / methods*
  • Rats
  • Rats, Sprague-Dawley


  • Insulin